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Edward J Olhava Selected Research

Protein Methyltransferases

1/2017Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia.
12/2015Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target.
9/2014DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

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Edward J Olhava Research Topics

Disease

5Leukemia
01/2017 - 03/2013
5Neoplasms (Cancer)
12/2015 - 04/2009
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2014
1Weight Loss (Weight Reduction)
08/2013
1Hematologic Neoplasms (Hematological Malignancy)
03/2013
1Necrosis
09/2010
1B-Cell Lymphoma (Lymphoma, B Cell)
09/2010
1Wounds and Injuries (Trauma)
08/2010

Drug/Important Bio-Agent (IBA)

3Histones (Histone)IBA
01/2017 - 08/2010
3Protein MethyltransferasesIBA
01/2017 - 09/2014
3EPZ-5676IBA
09/2014 - 08/2013
2tetrahydrofuranIBA
09/2014 - 05/2014
2ChromatinIBA
09/2014 - 03/2013
2Histone MethyltransferasesIBA
05/2014 - 08/2013
2Proteasome Endopeptidase Complex (Proteasome)IBA
09/2010 - 04/2009
2UbiquitinIBA
09/2010 - 04/2009
2EnzymesIBA
08/2010 - 04/2009
1Pharmaceutical PreparationsIBA
12/2015
1Cytarabine (Cytosar-U)FDA LinkGeneric
09/2014
1Daunorubicin (Cerubidine)FDA LinkGeneric
09/2014
1Puromycin AminonucleosideIBA
05/2014
1Oncogene Proteins (Oncogene Protein)IBA
03/2013
1Lysine (L-Lysine)FDA Link
03/2013
1NF-kappa B (NF-kB)IBA
09/2010
1Peptides (Polypeptides)IBA
09/2010
1LuciferasesIBA
09/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2010
1DNA (Deoxyribonucleic Acid)IBA
08/2010
1Proteins (Proteins, Gene)FDA Link
08/2010
1Cullin Proteins (Cullins)IBA
04/2009
1Ligases (Synthetase)IBA
04/2009